A profile of Diane Havlir and her work in ending the HIV/AIDS epidemic, from co-founding the much-admired Getting to Zero campaign in San Francisco to her Sustainable East African Research on Community Health (SEARCH) study in a fishing village in Kenya. Both efforts include the three pillars that are central to stopping the epidemic – preventing HIV infection with PrEP, testing, treating people immediately upon diagnosis of HIV, and retaining people in HIV care.